'Make or break': What to know about US-Iran talks in Pakistan

'Make or break': What to know about US-Iran talks in Pakistan Submitted by Yasmine El-Sabawi on Fri, 04/10/2026 - 18:34 The key deliverable may simply be the willingness of all parties to meet again A billboard promotes Saturday's Pakistan-mediated ceasefire talks between the US and Iran, in Islamabad, Pakistan, on 10 April 2026 (Waseem Khan/Reuters) Off When US Vice President JD Vance boarded his flight to Islamabad, Pakistan, on Friday morning in Washington, DC, he struck a relatively upbeat, more conciliatory tone than his boss, President Donald Trump, ahead of the high-stakes ceasefire talks with Iran. "We’re looking forward to the negotiation. I think it's going to be positive," Vance told reporters of the negotiations slated for Saturday morning and mediated by Pakistan, a friendly nation to both sides.